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The Efficacy Of Intravenous Pulse Cyclophosphamide
Wi Fi Radio Mahidol University Annual Research Abstracts 2000 107
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Broadband Access Results : Sixteen infants developed symptomatic PDA, 4 in the indomethacin group and 12 in the placebo group. The decrease in incidence of PDA is statistically significant. But when the data was analyzed separately for the VLBW and ELBW groups. The effects were only significantly different in ELBW but not yet significant in the VLBW group. There was statistically significant difference in the incidence of severe intraventricular hemorrhage (IVH) (grade 3 or higher) in the ELBW infants.
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Broadband Service Conclusion : Intravenous indomethacin therapy given to VLBW infants with a birth weight of less than 1250 g decreased incidence of symptomatic PDA with no significant permanent side effects. The effect was markedly noticable in ELBW infants. Incidence of severe IVH was also markedly decreased in the ELBW infants.
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Broadband Connection (J Med Assoc Thai 1999; 82(Suppl 1):S87) THE EFFICACY OF INTRAVENOUS PULSE CYCLOPHOSPHAMIDE IN THE TREATMENT OF SEVERE LUPUS NEPHRITIS IN CHILDREN
Palm Wi Fi Card Kanchana Tangnararatchakit, Chaleomsri Tapaneya-Olarn, Wiwat Tapaneya-Olarn Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.
Belkin Fi Phone Wi Background: The intermittent intravenous cyclophosphamide in the treatment of lupus nephritis in adults is well tolerated and associated with clinical improvement and long term stability of renal function. However, there are few reports about the efficacy of intravenous pulse cyclophosphamide (IPC) of severe lupus nephritis in children.
Nintendo Ds Wi Fi Objective: To evaluate the clinical efficacy, renal function, renal outcome and complications of IPC therapy in children with severe lupus nephritis.
Wi Fi Toy Method: Prospective study.
Wi Fi Hot Spot Patients: Children with severe lupus nephritis have been followed up for at least 6 months. Treatment regimen: Intravenous pulse cyclophosphamide 0.5-0.75 g/m2 given monthly for 6 months with subsequent doses given at 2-3 months interval up to 3 years and combined with low dose oral prednisolone therapy.
Wi Fi Services Results: Thirty-one children (mean age : 12.31 + 2.03 years; female : male = 24:7) with severe lupus nephritis received IPC therapy. 24 out of 28 patients (85.7%) had diffuse proliferative glomerulonephritis. After 3 months of treatment, most patients were clinically improved as evidenced by significant improvements in 24-hour urine protein, creatinine clearance, serum creatinine, BUN, serum albumin and C3 level. These improvements were sustained up to 18 months and were accompanied by a significant reduction in prednisolone dosage. Renal outcome at the last follow-up (range = 6-76 months) demonstrated that twelve patients (38.7%) had complete remission, 18 patients (58.0%) still had significant proteinuria and only one had serum creatinine of 1.6 mg/dl at 42 months. One child progressed to end stage renal diseases during IPC therapy. Five patients had severe infections during the treatment resulting in one death. Hemorrhagic cystitis and malignancies were not found.
Wi Fi Connection (J Med Assoc Thai 1999; 82(Suppl 1):S104)
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